Mouse Genome Informatics
tg
    Tg(PML-RARA)556Kog/?
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• epidermal papillomatosis
• mutants develop acute promyelocytic leukemia between 3 and 9 months of age, with a median age of 174 days
• mixed hematopoiesis of normal bone marrow is completely replaced by leukemic cells, splenic and lymphatic architecture is effaced and leukemia extends throughout the hepatic parenchyma
• both preleukemic state and the leukemia can be transplanted to wild-type mice and the preleukemia progresses to acute promyelocytic leukemia

immune system
• impaired neutrophil maturation early in life

hematopoietic system
• impaired neutrophil maturation early in life

cardiovascular system
• some leukemic mutants hemorrhage spontaneously

homeostasis/metabolism
• leukemic mutants are abnormally susceptible to bleeding after injections
• some mutants exhibit fibrin thrombi in pulmonary blood vessels but not in other organs

integument
• epidermal papillomatosis

cellular
• impaired neutrophil maturation early in life

Mouse Models of Human Disease
OMIM IDRef(s)
Acute Promyelocytic Leukemia; APL 612376 J:39327