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Phenotypes Associated with This Genotype
Genotype
MGI:3815135
Allelic
Composition
Tg(PML-RARA)556Kog/?
Genetic
Background
involves: FVB/N
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phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• epidermal papillomatosis
• mutants develop acute promyelocytic leukemia between 3 and 9 months of age, with a median age of 174 days
• mixed hematopoiesis of normal bone marrow is completely replaced by leukemic cells, splenic and lymphatic architecture is effaced and leukemia extends throughout the hepatic parenchyma
• both preleukemic state and the leukemia can be transplanted to wild-type mice and the preleukemia progresses to acute promyelocytic leukemia

immune system
• impaired neutrophil maturation early in life

hematopoietic system
• impaired neutrophil maturation early in life

cardiovascular system
• some leukemic mutants hemorrhage spontaneously

homeostasis/metabolism
• leukemic mutants are abnormally susceptible to bleeding after injections
• some mutants exhibit fibrin thrombi in pulmonary blood vessels but not in other organs

integument
• epidermal papillomatosis

cellular
• impaired neutrophil maturation early in life

Mouse Models of Human Disease
OMIM ID Ref(s)
Acute Promyelocytic Leukemia; APL 612376 J:39327


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory