Phenotypes Associated with This Genotype

Genotype
MGI:3815089

• Allelic Composition: Cxadr^tm2Know/Cxadr^tm2Know
• Genetic Background: involves: 129 * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:140870 )

• embryos generally die between E11.5 and E12.5

cardiovascular system

pericardial effusion ( J:140870 )

• some embryos have evidence of hemorrhage and a large pericardial effusion at E10.5-E11.5

absent heartbeat ( J:140870 )

• the heartbeat stops in embryos by E12.5

abnormal heart electrocardiography waveform feature ( J:140870 )

• the interval between the beginning of the A-wave and the beginning of the aortic outflow (a proxy for PR interval) is reduced by a third in all E10.5-E11.5 embryos

homeostasis/metabolism

pericardial effusion ( J:140870 )

• some embryos have evidence of hemorrhage and a large pericardial effusion at E10.5-E11.5