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Phenotypes Associated with This Genotype
Genotype
MGI:3815037
Allelic
Composition
Ly6atm1Pmf/Ly6atm1Pmf
Genetic
Background
C.129P2-Ly6atm1Pmf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ly6atm1Pmf mutation (0 available); any Ly6a mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the number of ostoblast colony forming units cultured from bone marrow of 2-month old mice is half that of controls (J:83409)
• in vitro bone nodule formation is reduced by more than half in these bone marrow cultures (J:83409)
• committed osteoblast progenitors have a 7% increase in doubling time compared to controls (J:83409)
• the number of osteoblast progenitors isolated from bone marrow cultures is reduced (J:83409)
• however, the ratio of osteoblast progenitors to total number of stromal progenitors is the same (J:83409)
• the number of ostoblast colony forming units cultured from bone marrow of 2-month old mice is half that of controls (J:83409)
• in vitro bone nodule formation is reduced by more than half in these bone marrow cultures (J:83409)
• committed osteoblast progenitors have a 7% increase in doubling time compared to controls (J:83409)
• the number of osteoblast progenitors isolated from bone marrow cultures is reduced (J:83409)
• however, the ratio of osteoblast progenitors to total number of stromal progenitors is the same (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)
• the absolute number of osteoclasts is reduced by more than 40% in both 2- and 9- month old femurs (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• the absolute number of osteoclasts is reduced by more than 40% in both 2- and 9- month old femurs (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• bone mineral content does not change between 2 months of age to 12 months of age while mineral content is increased in wild-type mice during this time period (J:83409)
• bone mineral content does not change between 2 months of age to 12 months of age while mineral content is increased in wild-type mice during this time period (J:83409)
• femurs have 27% fewer trabeculae compared with control bones at 4 months of age and 58% compared with bones at 15 months of age (J:83409)
• femurs have 27% fewer trabeculae compared with control bones at 4 months of age and 58% compared with bones at 15 months of age (J:83409)
• mice one year of age have the same bone mass density as 8 week old mice, which is significantly less than the bone mass of one year old wild-type mice (J:83409)
• the greatest decrease in bone mass density occurs in vertebrae (J:83409)
• mice one year of age have the same bone mass density as 8 week old mice, which is significantly less than the bone mass of one year old wild-type mice (J:83409)
• the greatest decrease in bone mass density occurs in vertebrae (J:83409)
• the percent of osteoid in femurs are significantly lower in both 4- and 15- month old bones (J:83409)
• the percent of osteoid in femurs are significantly lower in both 4- and 15- month old bones (J:83409)
• bone formation is essentially normal at 2 months of age but is dramatically reduced by 6 months of age (J:83409)
• bone formation is essentially normal at 2 months of age but is dramatically reduced by 6 months of age (J:83409)
• bone formation is essentially normal at 2 months of age but is dramatically reduced by 6 months of age (J:83409)
• bone formation is essentially normal at 2 months of age but is dramatically reduced by 6 months of age (J:83409)
• compression testing of 15-month old vertebrae shows the bone is not as stiff and is substantially weaker and more compliant than bones from wild-type animals (J:83409)
• the yield stress and failure stress of vertebrae are reduced by about a third while the elastic modulus is half that of controls (J:83409)
• femurs from 15-month-old mice have a similar stiffness to wild-type bones but are weaker and considerably more brittle (J:83409)
• compression testing of 15-month old vertebrae shows the bone is not as stiff and is substantially weaker and more compliant than bones from wild-type animals (J:83409)
• the yield stress and failure stress of vertebrae are reduced by about a third while the elastic modulus is half that of controls (J:83409)
• femurs from 15-month-old mice have a similar stiffness to wild-type bones but are weaker and considerably more brittle (J:83409)

hematopoietic system
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)
• the total number of stromal progenitors found in bone marrow is reduced in 2- and 7- month old mice by 45% and 67%, respectively, compared to controls (J:83409)
• serial passaging of bone marrow stromal cultures reduces the number of stromal progenitors by more than half per passage, indicating a defect in self renewal (J:83409)
• the total number of stromal progenitors found in bone marrow is reduced in 2- and 7- month old mice by 45% and 67%, respectively, compared to controls (J:83409)
• serial passaging of bone marrow stromal cultures reduces the number of stromal progenitors by more than half per passage, indicating a defect in self renewal (J:83409)
• the absolute number of osteoclasts is reduced by more than 40% in both 2- and 9- month old femurs (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• the absolute number of osteoclasts is reduced by more than 40% in both 2- and 9- month old femurs (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)

adipose tissue
• bone marrow stroma contains two-thirds less adipocyte progenitors than controls (J:83409)
• bone marrow stroma contains two-thirds less adipocyte progenitors than controls (J:83409)

immune system
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)
• the absolute number of osteoclasts is reduced by more than 40% in both 2- and 9- month old femurs (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• the absolute number of osteoclasts is reduced by more than 40% in both 2- and 9- month old femurs (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)

cellular
• the number of ostoblast colony forming units cultured from bone marrow of 2-month old mice is half that of controls (J:83409)
• in vitro bone nodule formation is reduced by more than half in these bone marrow cultures (J:83409)
• committed osteoblast progenitors have a 7% increase in doubling time compared to controls (J:83409)
• the number of osteoblast progenitors isolated from bone marrow cultures is reduced (J:83409)
• however, the ratio of osteoblast progenitors to total number of stromal progenitors is the same (J:83409)
• the number of ostoblast colony forming units cultured from bone marrow of 2-month old mice is half that of controls (J:83409)
• in vitro bone nodule formation is reduced by more than half in these bone marrow cultures (J:83409)
• committed osteoblast progenitors have a 7% increase in doubling time compared to controls (J:83409)
• the number of osteoblast progenitors isolated from bone marrow cultures is reduced (J:83409)
• however, the ratio of osteoblast progenitors to total number of stromal progenitors is the same (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)
• osteoblast and splenic co-cultures generated less than 10% of the osteoclasts found in co-cultures of wild-type cells (J:83409)
• when mutant osteoblastic cells were used with wild-type splenocytes, markedly reduced numbers of wild-type osteoclasts are generated indicating a primary stromal cell defect in osteoclastogenesis (J:83409)

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteoporosis 166710 J:83409


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory