Phenotypes for Hoxa11 Hoxc11 Hoxd11 MGI:3814876 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

• absence of metanephric kidney development at E13.5 and birth

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

absent metanephros ( J:88686 )

• absence of metanephric kidney development at E13.5 and birth

absent ureteric bud ( J:88686 )

• absence of bud formation at E11.5

cellular

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

embryo

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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