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Phenotypes Associated with This Genotype
Genotype
MGI:3814728
Allelic
Composition
Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic
Background
C.129-Cx3cr1tm1Zm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Zm mutation (1 available); any Cx3cr1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice
• however, dark raised mice exhibit reduced numbers of subretinal microglial cells in the retina
• the retinal photoreceptor layer is thin at 2 months and degenerated at 4 months of age
• however, dark raised mice do not exhibit thinning or degeneration
• mice exhibit degeneration of the outer retina
• however, dark raised mice do not exhibit degeneration

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
age related macular degeneration 12 DOID:0110024 OMIM:613784
J:127548


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory