Mouse Genome Informatics
ht
    Brca2tm1Mbn/Brca2+
B6.Cg-Brca2tm1Mbn ApcMin
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size/body
N
• body weight of mice at time of sacrifice does not differ significantly from Apc-heterozygous or wild-type animals; weight gain over experiment duration is similar to that of wild-type animals (J:67445)

reproductive system
N
• only observed in 1/10 ENU-treated males, similar to wild-type males (1/9) (J:67445)

tumorigenesis
• females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5 (J:67445)
• no males develop mammary tumors (J:67445)

endocrine/exocrine glands
• females exhibit some adrenal hyperplasia, while none is observed in males (J:67445)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:67445