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Phenotypes Associated with This Genotype
Genotype
MGI:3814365
Allelic
Composition
Brca2tm1Mbn/Brca2+
Genetic
Background
B6.Cg-Brca2tm1Mbn ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Mbn mutation (0 available); any Brca2 mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• body weight of mice at time of sacrifice does not differ significantly from Apc-heterozygous or wild-type animals; weight gain over experiment duration is similar to that of wild-type animals

integument
• females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5
• no males develop mammary tumors

reproductive system
N
• only observed in 1/10 ENU-treated males, similar to wild-type males (1/9)

neoplasm
• females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5
• no males develop mammary tumors

endocrine/exocrine glands
• females exhibit some adrenal hyperplasia, while none is observed in males
• no males develop mammary tumors
• females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:67445


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory