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Phenotypes Associated with This Genotype
Genotype
MGI:3814365
Allelic
Composition
Brca2tm1Mbn/Brca2+
Genetic
Background
B6.Cg-Brca2tm1Mbn ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2tm1Mbn mutation (0 available); any Brca2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• body weight of mice at time of sacrifice does not differ significantly from Apc-heterozygous or wild-type animals; weight gain over experiment duration is similar to that of wild-type animals (J:67445)
• body weight of mice at time of sacrifice does not differ significantly from Apc-heterozygous or wild-type animals; weight gain over experiment duration is similar to that of wild-type animals (J:67445)

reproductive system
N
• only observed in 1/10 ENU-treated males, similar to wild-type males (1/9) (J:67445)
• only observed in 1/10 ENU-treated males, similar to wild-type males (1/9) (J:67445)

tumorigenesis
• females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5 (J:67445)
• no males develop mammary tumors (J:67445)
• females develop mammary tumors at an incidence rate of 23% with a mean tumor multiplicity rate of 0.3 +/- 0.5 (J:67445)
• no males develop mammary tumors (J:67445)

endocrine/exocrine glands
• females exhibit some adrenal hyperplasia, while none is observed in males (J:67445)
• females exhibit some adrenal hyperplasia, while none is observed in males (J:67445)

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:67445


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory