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Phenotypes Associated with This Genotype
Genotype
MGI:3814331
Allelic
Composition
Park2tm1Ykt/Park2tm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park2tm1Ykt mutation (0 available); any Park2 mutation (23 available)
Tg(Prp-GPR37)1Ryot mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 24 months
• in young animals
• at 12 months of age, the number of dopamine transporter and VMAT2+ cells is decreased compared to in wild-type mice
• at 6 months of age, mice exhibit a reduction in the number of TH+ neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis
• however, mice do not exhibit a change in hippocampal neurons at 24 months of age

cellular
• at 18 and 24 months, mice exhibit a 30% reduction in mitochondrial complex I activity compared to in wild type mice

behavior/neurological
N
• despite loss of dopaminergic neurons, mice exhibit normal behaviors

homeostasis/metabolism
• by 24 months
• in young animals

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive juvenile Parkinson disease 2 DOID:0060368 OMIM:600116
J:140326


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory