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Phenotypes Associated with This Genotype
Genotype
MGI:3813634
Allelic
Composition
Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (24 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (40 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival is seen beginning around 2 months of age
• death appears to result from excessive bleeding due to invasion of uterine blood vessels by tumor cells

reproductive system
• hyperplasia progresses to carcinoma by 3 weeks of age
• by P10, luminal and glandular epithelial hyperplasia are seen
• enlarged relative to conditional mutants that are wild type for Trp53

neoplasm
• hyperplasia progresses to carcinoma by 3 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Endometrial Cancer 608089 J:139053


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory