Mouse Genome Informatics
cn
    Pgrtm2(cre)Lyd/Pgr+
Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn

involves: 129 * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• impaired survival is seen beginning around 2 months of age
• death appears to result from excessive bleeding due to invasion of uterine blood vessels by tumor cells

reproductive system
• by P10, luminal and glandular epithelial hyperplasia are seen
• enlarged relative to conditional mutants that are wild type for Trp53

tumorigenesis
• hyperplasia progresses to carcinoma by 3 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Endometrial Cancer 608089 J:139053