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Phenotypes Associated with This Genotype
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 22 months of age, forebrain weight is decreased compared to in wild-type mice
• however, striatal cellular morphology is normal
• as mice age, lateral ventricles are progressively smaller in size than in wild-type mice
• at 6 months of age, mice exhibit intranuclear inclusion bodies that progressively increase in size and number as mice age
• at 8.5 months of age, inclusions are detected in Purkinje cells but are less numerous at 22 months of age

• female mice exhibit impaired performance on a rotarod compared to wild-type mice that progressively worsens between 10 and 16 months
• male mice exhibit impaired performance on a rotarod compared to wild-type mice
• male mice exhibit decreased locomotor activity compared to wild-type mice that is most pronounced in the first 5 minutes of testing


Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:139807

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory