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Phenotypes Associated with This Genotype
Genotype
MGI:3812399
Allelic
Composition
Zeb1tm1Yhi/Zeb1tm1Yhi
Genetic
Background
either: (involves: 129 * C3H * C57BL/6) or (involves: 129 * C57BL/6 * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb1tm1Yhi mutation (1 available); any Zeb1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells
• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth
• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

mortality/aging
• half of the mice die within a year from lymphomas
• all mice die by 550 days

neoplasm
• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells
• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth
• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

homeostasis/metabolism
• at 4 months of age, 64.3% of mice have enlargement of the abdomen due to ascities fluid

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelopathy, Htlv-1-Associated; HAM 159580 J:139194


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory