Mouse Genome Informatics
hm
    Zeb1tm1Yhi/Zeb1tm1Yhi
either: (involves: 129 * C3H * C57BL/6) or (involves: 129 * C57BL/6 * ICR)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• half of the mice die within a year from lymphomas
• all mice die by 550 days

tumorigenesis
• 84% of mice have T cell derived lymphomas that are mostly CD4 single positive T cells
• median onset of disease is 30 weeks after birth with early onset occurring 95 days after birth
• lymphoma cells had invaded various lymph nodes, including the thoracic, peripancreatic, mesenteric, perirenal, mesenteric, and other peripheral lymph nodes

homeostasis/metabolism
• at 4 months of age, 64.3% of mice have enlargement of the abdomen due to ascities fluid

Mouse Models of Human Disease
OMIM IDRef(s)
Myelopathy, Htlv-1-Associated; HAM 159580 J:139194