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Phenotypes Associated with This Genotype
Genotype
MGI:3812208
Allelic
Composition
Sulf1Gt(XM190)Byg/Sulf1Gt(XM190)Byg
Sulf2Gt(PST111)Byg/Sulf2Gt(PST111)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf1Gt(XM190)Byg mutation (0 available); any Sulf1 mutation (110 available)
Sulf2Gt(PST111)Byg mutation (1 available); any Sulf2 mutation (176 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 11% of mice die between weaning and 6 months of age

skeleton
• at P21, mice exhibit a smaller than normal skeleton
• 5 of 22 mice exhibit incomplete closure of the basisphenoid bone
• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
• 2 of 29 mice exhibit fusion of the anterior tips of the left and right mandible
• at E16.5, radius length is 89% of double heterozygotes
• at E18.5, the length of the radius is decreased to 93% of double heterozygotes
• at P21, the length of the radius is reduced to 91% of wild-type
• at E16.5, mice exhibit a decrease in the length of the proliferating zone to 90% of double heterozygotes
• however, the ossified and hypertrophic zones were normal in length and there is no difference in the rate of proliferation within the zone
• during development mice exhibit a reduction in the number of undifferentiated chondrocytes between sternebra 3 and 4 compared to in double heterozygotes indicating an acceleration of chondrocyte differentiation
• at E18.5, 85% of mice exhibit small bony bridges to broad connections between 2 or 3 sternebra
• at P0/P1, 100% of mice exhibit different degrees of sternebrae fusion that never involves more than 3 sternebrae
• 94% of mice exhibit fusion of sternebra 3 and 4 (65% complete) and 18% of mice exhibit a fusion of sternebra 2 and 3
• at E18.5, sternum length is decreased 94% of double heterozygotes
• at P21, sternum length is decreased 87% of wild-type
• at P21, mice exhibit a broadened sternum compared to in wild-type mice
• at P21, mice exhibit a small ribcage
• after P21, 94% of mice exhibit calcified fusion of up to 7 distal tail vertebrae
• 9 of 29 mice exhibit dorsally malformed second cervical vertebra
• 3 mice exhibit transformation of C2 into C1
• at P0/P1, mice exhibit fusion of ossification centers in the lumbar vertebrae
• at E18.5, 92% of mice exhibit connections in 1 to 5 vertebrae anterior to S2
• at P0/P1, all mice exhibit fusion of ossification centers in the sacral vertebrae
• at P21, 88% of mice exhibit split dorsal vertebrae compared to 22% of wild-type mice with 47% of mice exhibiting involvement of 2 to 6 vertebrae

craniofacial
• 5 of 22 mice exhibit incomplete closure of the basisphenoid bone
• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
• 2 of 29 mice exhibit fusion of the anterior tips of the left and right mandible

growth/size/body
• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
• some mice develop misaligned and over-grown incisors unlike in heterozygous mice
• at P21, occasionally strongly dwarfed mice are observed
• at P0, body weight is reduced to 91% of double heterozygote weights
• at P21, mice weight 70% of double heterozygotes
• however, surviving mice recover to normal weight during postnatal development

limbs/digits/tail
• at E16.5, radius length is 89% of double heterozygotes
• at E18.5, the length of the radius is decreased to 93% of double heterozygotes
• at P21, the length of the radius is reduced to 91% of wild-type
• after P21, 94% of mice exhibit calcified fusion of up to 7 distal tail vertebrae


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory