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Phenotypes Associated with This Genotype
Genotype
MGI:3812201
Allelic
Composition
Krt14tm1Der/Krt14+
Tg(KRT5-cre/PGR)1Der/?
Genetic
Background
involves: 129X1/SvJ * FVB * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14tm1Der mutation (0 available); any Krt14 mutation (5 available)
Tg(KRT5-cre/PGR)1Der mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• after application of a topical antiprogestin, RU486, to the forelimbs and chest of newborn pups so that the cre transgene translocates from the cytoplasm to the nucleus of epidermal cells and becomes active, mice developed blisters filled with fluid on the front legs and paws
• blistering occurs within the basal layer of the epidermis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epidermolysis bullosa simplex Dowling-Meara type DOID:0060735 OMIM:131760
J:67320


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory