Mouse Genome Informatics
hm
    Pkd1tm2Jzh/Pkd1tm2Jzh
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• about 10% of embryos survive until birth
• embryos die as early as E13.5 with a peak between E14.5 and E16.5
• about 10% of embryos survive until birth

homeostasis/metabolism
• systemic edema is noted in mice that have survived until birth
• is noted in mice that have survived until birth

renal/urinary system
• kidney cysts are first detectable in embryos at E15.5
• new born mice have polycystic kidneys with large cysts visibly disrupting the kidney architecture

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:140012