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Phenotypes Associated with This Genotype
Genotype
MGI:3811281
Allelic
Composition
Pkd1tm2Jzh/Pkd1tm2Jzh
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd1tm2Jzh mutation (0 available); any Pkd1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 10% of embryos survive until birth
• embryos die as early as E13.5 with a peak between E14.5 and E16.5
• about 10% of embryos survive until birth

homeostasis/metabolism
• systemic edema is noted in mice that have survived until birth
• is noted in mice that have survived until birth

renal/urinary system
• kidney cysts are first detectable in embryos at E15.5
• new born mice have polycystic kidneys with large cysts visibly disrupting the kidney architecture

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 1; PKD1 173900 J:140012


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory