Mouse Genome Informatics
hm
    Pkd1tm3.1Jzh/Pkd1tm3.1Jzh
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• the 50% of mice that survive until birth die shortly thereafter
• only half the expected number of homozygotes survive are born at birth

homeostasis/metabolism
• systemic edema is noted in mice that have survived until birth
• is noted in mice that have survived until birth

renal/urinary system
• kidney cysts are first detectable in embryos at E15.5
• new born mice have polycystic kidneys with large cysts visibly disrupting the kidney architecture

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:140012