Phenotypes Associated with This Genotype

Genotype
MGI:3810837

• Allelic Composition: Hoxa11^tm1Mrc/Hoxa11^tm1Mrc; Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased lumbar vertebrae number ( J:78766 )

• 8 instead of 6

renal/urinary system

renal hypoplasia ( J:88686 )

• bilateral kidney hypoplasia present at birth

single kidney ( J:88686 )

• occasionally seen

abnormal ureter development ( J:88686 )

• at E13.5 the ureter's route to the kidney is circuitous and abnormal; transversing anteriorly around the kidney to the lateral side before entering the kidney

limbs/digits/tail

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes