Phenotypes Associated with This Genotype

Genotype
MGI:3810360

• Allelic Composition: Hprt1^b-m1/Y
• Genetic Background: involves: 129 * 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:115724 )

♂N • mice exhibit overall similar behavior as observed in wild-type mice in open field, bridge, passive avoidance and apomorphine-induced activity tests

abnormal motor coordination/balance ( J:115724 )

♂ • male mice make less slips when climbing than escape platform in a swim test compared to Hprt1^b-m2 male mice

decreased vertical activity ( J:115724 )

♂ • male mice spend more time in the center of an open field than Hprt1^b-m2 male mice

homeostasis/metabolism

decreased dopamine level ( J:115724 )

♂ • striatal concentrations of dopamine are lower than in wild-type mice