Phenotypes Associated with This Genotype

Genotype
MGI:3810154

• Allelic Composition: Trpc3^tm1.1Akon/Trpc3^tm1.1Akon
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired limb coordination ( J:139695 )

• reduced ability to walk on an irregularly spaced ladder or on a thin elevated beam

abnormal gait ( J:139695 )

• hind feet track outside of the path defined by the body diameter

nervous system

nervous system phenotype ( J:139695 )

N • normal size and layered structure of cerebellum

N • normal Purkinje cell morphology

abnormal excitatory postsynaptic currents ( J:139695 )

• the mGluR1 (Grm1) mediated slow EPSC is completely abolished

• synaptically evoked dendritic calcium ion signal is unaffected