Phenotypes Associated with This Genotype

Genotype
MGI:3810061

• Allelic Composition: mt-Nd6^m1Dwa
• Genetic Background: involves: C3H/An * C57BL/6J * M. m. domesticus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:132659 )

• activity of complex I and IV are decreased in the brain, heart, liver and skeletal muscles compared to in wild-type mice

• however, this phenotype is not affected by the proportion of mitochondria with the mt-Nd6^m1Dwa allele and was not maintained in subsequent generations due to preferential loss of oocytes containing mt-Nd6