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Phenotypes Associated with This Genotype
Genotype
MGI:3809649
Allelic
Composition		 Il12atm1Jm/Il12atm1Jm
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12atm1Jm mutation (2 available); any Il12a mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:139001 )
• NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG

hematopoietic system
abnormal NK cell physiology ( J:139001 )
• NK cells in vivo make much about 7-fold less IFN-gamma in response to injections of the TLR9 agonist CpG

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory