Phenotypes Associated with This Genotype

Genotype
MGI:3809636

• Allelic Composition: Camkk2^tm1.1Arm/Camkk2^tm1.1Arm
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:136219 )

• mice gain less weight when fed a low fat or high fat diet than similarly treated wild-type mice

decreased circulating leptin level ( J:136219 )

• compared to in wild-type mice when fed a high fat diet

increased body temperature ( J:136219 )

• when fed normal chow

abnormal glucose homeostasis ( J:136219 )

• when fed a high fat diet, mice exhibit are protected from diet-induced changes in insulin action and glucose sensitivity observed in similarly treated wild-type mice

improved glucose tolerance ( J:136219 )

• mice fed a high fat diet exhibit improved glucose tolerance compared to similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:136219 )

• unlike in wild-type mice, Ghrelin does not stimulate increased food consumption

adipose tissue

increased brown adipose tissue amount ( J:136219 )

• scapular brown adipose tissue weight is increased compared to in wild-type mice fed normal chow

decreased total body fat amount ( J:136219 )

• whether fed a low or high fat diet, mice exhibit decreased adipocity compared to wild-type mice

increased percent body fat/body weight ( J:136219 )

• compared to wild-type mice when fed a low fat diet

behavior/neurological

decreased food intake ( J:136219 )

• mice eat less on a low or high fat diet compared to wild-type mice

decreased compensatory feeding amount ( J:136219 )

• mice exhibit decreased feeding after a fast compared to wild-type mice

growth/size/body

decreased susceptibility to diet-induced obesity ( J:136219 )

• mice gain less weight when fed a low fat or high fat diet than similarly treated wild-type mice