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Phenotypes Associated with This Genotype
Genotype
MGI:3809578
Allelic
Composition
Neurog3tm1Fgu/Neurog3tm1Fgu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1Fgu mutation (0 available); any Neurog3 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die 2 to 3 days after birth

digestive/alimentary system
• unlike in wild-type mice, exocrine cells exhibit abnormal polarity and random nuclei positions
• accumulation of zymogen granules in acinar cells

homeostasis/metabolism
• 2 days after birth

growth/size/body
• 2 days after birth, mice exhibit decreased weight and dehydration compared to wild-type mice

endocrine/exocrine glands
• unlike in wild-type mice, exocrine cells exhibit abnormal polarity and random nuclei positions
• accumulation of zymogen granules in acinar cells
• at E15.5, mice lack glucagon expressing cells unlike in wild-type mice
• at E15.5, mice lack insulin expressing cells unlike in wild-type mice
• mice lack Langerhans islets at birth
• however, absence of endocrine precursors in the pancreas is not due to increased apoptosis

renal/urinary system


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory