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Phenotypes Associated with This Genotype
Genotype
MGI:3809475
Allelic
Composition
Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz
Genetic
Background
involves: C57BL/6 * C57BL/10Sn * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cells from mice immunized with human collagen have higher responses to collagen-derived peptides
• in almost all cases, these peptides need to be presented by the transgenic MHC-complex and not the endogenous MHC to elicit a response
• mice are highly susceptible to arthritis induced by human collagen with incidence rates between 88% to 100% by 50 days post-injection
• mice have marked swelling and erythema of the hind and fore paws after human collagen administration
• inflammation frequently includes the wrist and ankle with massive infiltration of inflammatory cells leading to erosion of articular surfaces
• littermate control mice do not develop disease when injected human collagen
• mice immunized with human collagen produce at least 5-fold more antibody to mouse collagen than do non-transgenic controls

skeleton
• mice are highly susceptible to arthritis induced by human collagen with incidence rates between 88% to 100% by 50 days post-injection
• mice have marked swelling and erythema of the hind and fore paws after human collagen administration
• inflammation frequently includes the wrist and ankle with massive infiltration of inflammatory cells leading to erosion of articular surfaces
• littermate control mice do not develop disease when injected human collagen

hematopoietic system
• T cells from mice immunized with human collagen have higher responses to collagen-derived peptides
• in almost all cases, these peptides need to be presented by the transgenic MHC-complex and not the endogenous MHC to elicit a response

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:108635


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory