Phenotypes Associated with This Genotype

Genotype
MGI:3809298

• Allelic Composition: Dicer1^tm1Snj/Dicer1^tm1Snj
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:139257 )

• mouse embryonic fibroblasts transfected with an adenovirus cre fail to produce micro RNAs and exhibit increased DNA damage that leads to premature senescence

abnormal mitosis ( J:139257 )

• mouse embryonic fibroblasts transfected with an adenovirus cre exhibit an increase in the number of cells in S phase

decreased cell proliferation ( J:139257 )

• mouse embryonic fibroblasts transfected with an adenovirus cre cell proliferation is slowed compared to in wild-type cells

early cellular replicative senescence ( J:139257 )

• mouse embryonic fibroblasts transfected with an adenovirus cre exhibit premature senescence associated with increased DNA damage

decreased DNA replication ( J:139257 )

• mouse embryonic fibroblasts transfected with an adenovirus cre undergo less DNA replication than in wild-type cells

homeostasis/metabolism

decreased DNA replication ( J:139257 )

• mouse embryonic fibroblasts transfected with an adenovirus cre undergo less DNA replication than in wild-type cells