Analysis Tools
craniofacial
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• some mice exhibit periodontal problems around the mandibular molars including bone loss, widened interdental spaces and bifurcated openings in relation to the roots of the first and sometimes second molar unlike in wild-type mice
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• incisors are opaque, exhibit severe dentin abrasion and are coated in a thin layer of calcified material unlike in wild-type mice
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• molars are coated in a thin layer of calcified material and show overt occlusal wear unlike in wild-type mice
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• some molar crowns exhibit an accumulation of calcified material
• mineralized crowns are thinner and less dense than in wild-type mice
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• minor
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• beneath the cell, enamel surfaces are lumpy laterally more often than mesially unlike in wild-type mice
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• mandibular crown mineralization at 2 weeks is reduced compared to in wild-type and heterozygous mice
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• mice lack true enamel
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• incisors exhibit severe dentin abrasion
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• molars show overt occlusal wear unlike in wild-type mice
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skeleton
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• incisors are opaque, exhibit severe dentin abrasion and are coated in a thin layer of calcified material unlike in wild-type mice
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• molars are coated in a thin layer of calcified material and show overt occlusal wear unlike in wild-type mice
|
|
• some molar crowns exhibit an accumulation of calcified material
• mineralized crowns are thinner and less dense than in wild-type mice
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• minor
|
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• beneath the cell, enamel surfaces are lumpy laterally more often than mesially unlike in wild-type mice
|
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• mandibular crown mineralization at 2 weeks is reduced compared to in wild-type and heterozygous mice
|
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• mice lack true enamel
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• incisors exhibit severe dentin abrasion
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• molars show overt occlusal wear unlike in wild-type mice
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homeostasis/metabolism
| N |
• no abnormalities are observed in blood levels of calcium, phosphate, glucose, or alkaline phosphatase
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growth/size/body
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• some mice exhibit periodontal problems around the mandibular molars including bone loss, widened interdental spaces and bifurcated openings in relation to the roots of the first and sometimes second molar unlike in wild-type mice
|
|
• incisors are opaque, exhibit severe dentin abrasion and are coated in a thin layer of calcified material unlike in wild-type mice
|
|
• molars are coated in a thin layer of calcified material and show overt occlusal wear unlike in wild-type mice
|
|
• some molar crowns exhibit an accumulation of calcified material
• mineralized crowns are thinner and less dense than in wild-type mice
|
|
• minor
|
|
• beneath the cell, enamel surfaces are lumpy laterally more often than mesially unlike in wild-type mice
|
|
• mandibular crown mineralization at 2 weeks is reduced compared to in wild-type and heterozygous mice
|
|
• mice lack true enamel
|
|
• incisors exhibit severe dentin abrasion
|
|
• molars show overt occlusal wear unlike in wild-type mice
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