Phenotypes Associated with This Genotype

Genotype
MGI:3807779

• Allelic Composition: B2m^tm1Jae/B2m^tm1Jae; Tox^tm1.1Kay/Tox^tm1.1Kay
• Genetic Background: involves: 129S6/SvEvTac * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell number ( J:131287 )

• about twice as much CD8⁺ T cells are found in the thymus of double knockouts compared to mice homozygote for just the B2m^tm1Jae allele

• about 5-fold more CD8⁺ T cells are found in the spleen of double knockouts compared to mice homozygote for just the B2m^tm1Jae allele

• numbers of CD8⁺ T cells in both the thymus and spleen are still well below normal numbers indicating the vast majority of CD8⁺ T cells are Class I-dependent

hematopoietic system

abnormal CD8-positive, alpha-beta T cell number ( J:131287 )

• about twice as much CD8⁺ T cells are found in the thymus of double knockouts compared to mice homozygote for just the B2m^tm1Jae allele

• about 5-fold more CD8⁺ T cells are found in the spleen of double knockouts compared to mice homozygote for just the B2m^tm1Jae allele

• numbers of CD8⁺ T cells in both the thymus and spleen are still well below normal numbers indicating the vast majority of CD8⁺ T cells are Class I-dependent