About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3807714
Allelic
Composition
Genetic
Background
A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• at 30 days of age a hair cell lesion is found in the basal turn of the cochlea in A/J although the spiral ganglion appear normal in all turns including the basal turn
• at 9 weeks of age there is a massive loss of inner and outer hair cells from the mid-basal turn of the cochlea and a moderate loss of inner and outer hair cells from the mid-apical turn
• at 20 weeks of age there is a massive loss of inner and outer hair cells throughout the cochlea, except for the apical 10%
• loss of cochlear hair cells begins around 16 days of age, spreads from base to apex, and outer hair cells are more vulnerable to loss than are inner hair cells

nervous system
• at 30 days of age a hair cell lesion is found in the basal turn of the cochlea in A/J although the spiral ganglion appear normal in all turns including the basal turn
• at 9 weeks of age there is a massive loss of inner and outer hair cells from the mid-basal turn of the cochlea and a moderate loss of inner and outer hair cells from the mid-apical turn
• at 20 weeks of age there is a massive loss of inner and outer hair cells throughout the cochlea, except for the apical 10%
• loss of cochlear hair cells begins around 16 days of age, spreads from base to apex, and outer hair cells are more vulnerable to loss than are inner hair cells

immune system
• subsequent to ip injection of 15mg/kg LPS, A/J mice show highly diminished neutrophil infiltration into hepatic sinusoids compared with C57BL/6J controls
• subsequent to ip injection of 15mg/kg LPS, A/J mice have decreased hepatic, pulmonary and intestinal neutrophil infiltrate compared with C57BL/6J mice
• moderately susceptible to mouse-adapted SARS-CoV infection, including moderate and transient weight loss

hematopoietic system
• subsequent to ip injection of 15mg/kg LPS, A/J mice show highly diminished neutrophil infiltration into hepatic sinusoids compared with C57BL/6J controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/14/2021
MGI 6.17
The Jackson Laboratory