Phenotypes Associated with This Genotype

Genotype
MGI:3807520

• Allelic Composition: Gpsm1^tm1.1Lajb/Gpsm1^tm1.1Lajb
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:138126 )

• becomes apparent at 10 - 12 weeks of age

adipose tissue

decreased white adipose tissue amount ( J:138126 )

• apparent at 10 weeks of age

• by 5.5 months of age body fat is reduced by 6% compared to controls

behavior/neurological

abnormal eating behavior ( J:138126 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:138126 )

N • despite the reduction in body fat, serum glucose, total cholesterol and triglyceride levels are similar to controls

increased energy expenditure ( J:138126 )

• nocturnal, but not daytime, energy expenditure is increased by 30% compared to controls

• however, there is no apparent difference in locomotor activity compared to controls

cardiovascular system

cardiovascular system phenotype ( J:138126 )

N • despite differences in mean arterial pressure, heart rate and diurnal variation in heart rate are similar to controls

decreased mean systemic arterial blood pressure ( J:138126 )

• reduction in mean arterial pressure and diurnal variations in mean arterial pressure

increased vasodilation ( J:138126 )

• increased in sensitivity to the vasodilator sodium nitroprusside as indicted by impaired compensation following vasodilation

nervous system

nervous system phenotype ( J:138126 )

N • despite expression in the brain in wild-type mice, no obvious defects in brain morphology are detected at 3 weeks, 6 weeks or 6 months of age

abnormal baroreceptor physiology ( J:138126 )

• enhanced gain of the spontaneous baroreceptor reflex

muscle

increased vasodilation ( J:138126 )

• increased in sensitivity to the vasodilator sodium nitroprusside as indicted by impaired compensation following vasodilation