Phenotypes Associated with This Genotype

Genotype
MGI:3806697

• Allelic Composition: Igkc^tm1Bgmn/Igkc^tm1Bgmn; Igl^tm2.1Bgmn/Igl^tm2.1Bgmn
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:130864 )

• B cell development is partially blocked at the small pre-B cell stage

• cells are released from the bone marrow as B220⁺CD21/CD35⁺ B cells

• there is also a small population (0.8%) of B cells expressing Igbeta

abnormal immunoglobulin heavy chain V(D)J recombination ( J:130864 )

• many heavy chain antibodies produced by B cells in these mice lack the Ch1 exon

abnormal plasma cell morphology ( J:130864 )

• plasma cells secrete heavy-chain only IgG

decreased IgG level ( J:130864 )

• reduced but detectable amounts of IgG antibody are found in the sera

• antibodies consist of heavy chain only homodimers

• antigen-specific IgG can be generated by several immunizations of OVA peptide

• these immunizations also result in increases to total IgG levels

decreased IgM level ( J:130864 )

• IgM is not present in the sera

hematopoietic system

abnormal B cell differentiation ( J:130864 )

• B cell development is partially blocked at the small pre-B cell stage

• cells are released from the bone marrow as B220⁺CD21/CD35⁺ B cells

• there is also a small population (0.8%) of B cells expressing Igbeta

abnormal immunoglobulin heavy chain V(D)J recombination ( J:130864 )

• many heavy chain antibodies produced by B cells in these mice lack the Ch1 exon

abnormal plasma cell morphology ( J:130864 )

• plasma cells secrete heavy-chain only IgG

decreased IgG level ( J:130864 )

• reduced but detectable amounts of IgG antibody are found in the sera

• antibodies consist of heavy chain only homodimers

• antigen-specific IgG can be generated by several immunizations of OVA peptide

• these immunizations also result in increases to total IgG levels

decreased IgM level ( J:130864 )

• IgM is not present in the sera