Phenotypes Associated with This Genotype

Genotype
MGI:3806620

• Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi; Tg(Nes-cre)1Wme/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired autophagy ( J:130839 )

• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins

• these inclusion bodies are visible two days after birth and grow in size and number during development

increased neuron apoptosis ( J:130839 )

• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex

homeostasis/metabolism

impaired autophagy ( J:130839 )

• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins

• these inclusion bodies are visible two days after birth and grow in size and number during development

nervous system

absent hippocampus pyramidal cells ( J:130839 )

• large pyramidal neurons in the hippocampus are absent

absent cerebral cortex pyramidal cells ( J:130839 )

• large pyramidal neurons in the cerebral cortex are absent

axon degeneration ( J:130839 )

• myelinated axons of the cerebellar nuclei are frequently enlarged and contain aberrant membranous structures and degenerated material

abnormal nervous system physiology ( J:130839 )

• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins

• these inclusion bodies are visible two days after birth and grow in size and number during development

increased neuron apoptosis ( J:130839 )

• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex

behavior/neurological

limb grasping ( J:130839 )

• abnormal limb clasping is observed in mice

tremors ( J:130839 )

• is observed