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Phenotypes Associated with This Genotype
Genotype
MGI:3806486
Allelic
Composition
Lrp5r18/Lrp5r18
Genetic
Background
C57BL/6J-Lrp5r18
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5r18 mutation (0 available); any Lrp5 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hyperpermeable retinal vessels
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development
• immature endothelial cells in lumen-less capillaries are associated with an attenuated vessel network

vision/eye
• hyperpermeable retinal vessels
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development
• immature endothelial cells in lumen-less capillaries are associated with an attenuated vessel network

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
exudative vitreoretinopathy DOID:0050535 OMIM:PS133780
J:135279


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2021
MGI 6.16
The Jackson Laboratory