Phenotypes Associated with This Genotype

Genotype
MGI:3806249

• Allelic Composition: Ndst3^tm1.1Grob/Ndst3^tm1.1Grob
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:138557 )

• males exhibit decreased anxiety-related behaviors in an elevated plus maze due to moderate heparan-sulfate undersulfation

hematopoietic system

decreased lymphocyte cell number ( J:138557 )

• the relative number of circulating lymphocytes is reduced 35% compared to in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:138557 )

• the relative number of CD8+ T cells in the spleen is reduced compared to in wild-type mice

homeostasis/metabolism

decreased circulating cholesterol level ( J:138557 )

• reduced 23%

decreased circulating HDL cholesterol level ( J:138557 )

• reduced 31%

immune system

decreased lymphocyte cell number ( J:138557 )

• the relative number of circulating lymphocytes is reduced 35% compared to in wild-type mice

decreased CD8-positive, alpha-beta T cell number ( J:138557 )

• the relative number of CD8+ T cells in the spleen is reduced compared to in wild-type mice

nervous system

nervous system phenotype ( J:138557 )

N • despite expression in the brain and involvement in disaccharide sulfation, no cellular changes are observed in the brain