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Phenotypes Associated with This Genotype
Genotype
MGI:3806097
Allelic
Composition
Vsig4tm1Gne/Vsig4tm1Gne
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsig4tm1Gne mutation (0 available); any Vsig4 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following infection with Listeria monocytogenes, mice exhibit increased mortality compared to similarly treated wild-type mice

immune system
• following infection with Listeria monocytogenes, mice exhibit increased bacterial counts in the blood, spleen and lungs, increased serum cytokine levels, reduced splenocyte numbers by day 6 of infection, reduced bacterial clearance and increased mortality compared to similarly treated wild-type mice
• following infection with Staphylococcus aureus, mice exhibit increased blood and bacterial counts compared to in similarly treated wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory