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Phenotypes Associated with This Genotype
Genotype
MGI:3805706
Allelic
Composition		 Pdss2tm1Dalg/Pdss2tm1Dalg
Tg(NPHS2-cre)295Lbh/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdss2tm1Dalg mutation (0 available); any Pdss2 mutation (31 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
tubulointerstitial nephritis ( J:136670 )
• histological evidence of nephritis
abnormal renal tubule morphology ( J:136670 )
• extensive interstitial infiltration

homeostasis/metabolism
increased circulating cholesterol level ( J:136670 )
• elevated plasma cholesterol

immune system
tubulointerstitial nephritis ( J:136670 )
• histological evidence of nephritis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory