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Phenotypes Associated with This Genotype
Genotype
MGI:3805034
Allelic
Composition
Hps5ru2-mr/Hps5ru2-mr
Genetic
Background
B6.Cg-Hps5ru2-mr/Re
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hps5ru2-mr mutation (0 available); any Hps5 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• platelet ADP levels are much lower than in C57BL/6J controls
• platelet ATP levels are much lower than in C57BL/6J controls
• decreased number of platelet dense granules compared with C57BL/6J controls
• platelet serotonin levels are less than 7% of normal platelet serotonin levels (J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)

homeostasis/metabolism
• platelet serotonin levels are less than 7% of normal platelet serotonin levels (J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)
• bleed time averaging over 14 minutes after tail nick is much greater than the 3.8 minutes for C57BL/6J controls

cardiovascular system
• on an atherogenic diet homozygotes develop fewer and smaller aortic lesions than do C57BL/6J controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
platelet storage pool deficiency DOID:2223 OMIM:185050
J:7327


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory