Mouse Genome Informatics
hm
    Hps5ru2-mr/Hps5ru2-mr
B6.Cg-Hps5ru2-mr/Re
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• platelet ADP levels are much lower than in C57BL/6J controls
• platelet ATP levels are much lower than in C57BL/6J controls
• decreased number of platelet dense granules compared with C57BL/6J controls
• platelet serotonin levels are less than 7% of normal platelet serotonin levels (J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)

homeostasis/metabolism
• platelet serotonin levels are less than 7% of normal platelet serotonin levels (J:7327)
• platelet serotonin level is also lower than that of control when fed an atherogenic diet (J:29748)
• bleed time averaging over 14 minutes after tail nick is much greater than the 3.8 minutes for C57BL/6J controls

cardiovascular system
• on an atherogenic diet homozygotes develop fewer and smaller aortic lesions than do C57BL/6J controls

Mouse Models of Human Disease
OMIM IDRef(s)
Storage Pool Platelet Disease 185050 J:7327