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Phenotypes Associated with This Genotype
Genotype
MGI:3803707
Allelic
Composition
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbatm1(HBA)Tow mutation (1 available); any Hba mutation (12 available)
Hbbtm2(HBG1,HBB*)Tow mutation (1 available); any Hbb mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• abundant hemosiderin deposits (J:134980)
• abundant hemosiderin deposits (J:134980)
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels (J:134980)
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels (J:134980)
• erythroid progenitors are present in the hepatic sinusoids (J:134980)
• erythroid progenitors are present in the hepatic sinusoids (J:134980)
• slightly thalassemic (J:137709)
• slightly thalassemic (J:137709)
• many rigid elongated cells are seen in blood smears (J:134980)
• many rigid elongated cells are seen in blood smears (J:134980)
• massive expansion of the red pulp (J:134980)
• massive expansion of the red pulp (J:134980)
• complete loss of lymphoid follicular structure (J:134980)
• complete loss of lymphoid follicular structure (J:134980)

liver/biliary system
• pronounced congestion of intrahepatic vessels and aggregates of sickled red blood cells (J:134980)
• pronounced congestion of intrahepatic vessels and aggregates of sickled red blood cells (J:134980)
• abundant hemosiderin deposits (J:134980)
• abundant hemosiderin deposits (J:134980)
• pronounced congestion of intrahepatic vessels (J:134980)
• pronounced congestion of intrahepatic vessels (J:134980)
• abundant hemosiderin deposits in the Kupffer cells (J:134980)
• abundant hemosiderin deposits in the Kupffer cells (J:134980)

renal/urinary system
• engorgement and occlusion of renal blood vessels (J:134980)
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected (J:134980)
• engorgement and occlusion of renal blood vessels (J:134980)
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected (J:134980)
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected (J:134980)
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected (J:134980)

cardiovascular system
• engorgement and occlusion of renal blood vessels (J:134980)
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected (J:134980)
• engorgement and occlusion of renal blood vessels (J:134980)
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected (J:134980)
• abundant hemosiderin deposits (J:134980)
• abundant hemosiderin deposits (J:134980)
• pronounced congestion of intrahepatic vessels (J:134980)
• pronounced congestion of intrahepatic vessels (J:134980)
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels (J:134980)
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels (J:134980)

homeostasis/metabolism
• abundant hemosiderin deposits in the Kupffer cells (J:134980)
• abundant hemosiderin deposits in the Kupffer cells (J:134980)

immune system
• abundant hemosiderin deposits (J:134980)
• abundant hemosiderin deposits (J:134980)
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels (J:134980)
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels (J:134980)
• massive expansion of the red pulp (J:134980)
• massive expansion of the red pulp (J:134980)
• complete loss of lymphoid follicular structure (J:134980)
• complete loss of lymphoid follicular structure (J:134980)

Mouse Models of Human Disease
OMIM ID Ref(s)
Sickle Cell Anemia 603903 J:134980


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory