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Phenotypes Associated with This Genotype
Genotype
MGI:3803707
Allelic
Composition
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbatm1(HBA)Tow mutation (1 available); any Hba mutation (12 available)
Hbbtm2(HBG1,HBB*)Tow mutation (1 available); any Hbb mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• abundant hemosiderin deposits
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels
• erythroid progenitors are present in the hepatic sinusoids
• slightly thalassemic
• many rigid elongated cells are seen in blood smears
• massive expansion of the red pulp
• complete loss of lymphoid follicular structure

liver/biliary system
• pronounced congestion of intrahepatic vessels and aggregates of sickled red blood cells
• abundant hemosiderin deposits
• pronounced congestion of intrahepatic vessels
• abundant hemosiderin deposits in the Kupffer cells

renal/urinary system
• engorgement and occlusion of renal blood vessels
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected

cardiovascular system
• engorgement and occlusion of renal blood vessels
• occlusion is most obvious at the corticomedullary junctions where dilated capillaries are easily detected
• abundant hemosiderin deposits
• pronounced congestion of intrahepatic vessels
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels

homeostasis/metabolism
• abundant hemosiderin deposits in the Kupffer cells

immune system
• abundant hemosiderin deposits
• pooling of sinusoidal erythrocytes and vasoocclusion of splenic vessels
• massive expansion of the red pulp
• complete loss of lymphoid follicular structure

Mouse Models of Human Disease
OMIM ID Ref(s)
Sickle Cell Anemia 603903 J:134980


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory