Phenotypes Associated with This Genotype

Genotype
MGI:3803617

• Allelic Composition: Bnip3l^{Gt(XT0573)Wtsi}/Bnip3l^{Gt(XT0573)Wtsi}
• Genetic Background: B6.Cg-Bnip3l^{Gt(XT0573)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal erythrocyte morphology ( J:137609 )

decreased erythrocyte cell number ( J:137609 )

decreased mean corpuscular volume ( J:137609 )

polychromatophilia ( J:137609 )

abnormal reticulocyte morphology ( J:137609 )

• reticulocytes display abnormal shape

• while the number of immature reticulocytes is increased the number of mature reticulocyes is decreased compared to in wild-type mice

• a significant proportion of mature reticulocytes retain mitochondria unlike wild-type cells

• however, autophagosomes responsible for removal of mitochondria are present and removal of ribosomes and the nucleus is normal

reticulocytosis ( J:137609 )

• the number of reticulocytes is increased compared to in wild-type mice

abnormal erythrocyte physiology ( J:137609 )

• red blood cells exhibit faster clearance of with N-hydroxysuccinimido-biotin, shorter lifespan and greater induction of apoptosis signaling than wild-type cells

increased erythrocyte osmotic fragility ( J:137609 )

• red blood cells are osmotically fragile compared to wild-type cells