Phenotypes Associated with This Genotype

Genotype
MGI:3803344

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:137522 )

• impaired production of interferon beta in MEFs stimulated with dsRNA or Japanese encephalitis virus

• severely impaired production of type-I interferons in MEFs in response to mutant negative-sense ssRNA viruses lacking viral proteins that suppress interferon expression

• however, production of interferon beta in response to poly(I:C) is similar to controls

immune system

abnormal dendritic cell physiology ( J:137522 )

• impaired production of interferon beta in response to Sendai virus in bone marrow derived dendritic cells