About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3803094
Allelic
Composition
Gli3tm1.1Alj/Gli3tm1.1Alj
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm1.1Alj mutation (0 available); any Gli3 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• loss of diagnostic morphology of isthmus
• anterior isthmus region with characteristics of the cerebellum
• thicker than normal Purkinje region and axons disorganized
• dorsal mesencephalon, isthmus, and r1 not distinct at E10.5 and E12.5
• isthmus flexure less prominent
• tegmentum unaffected
• ventral nuclei containing dopaminergic neurons appear normal
• expanded mesencephalic ventricle at E10.5 and E12.5
• poorly formed
• loss of diagnostic morphology
• loss of diagnostic morphology
• overgrown tectum
• thickness of ventricular zone increased
• not clearly separated from the isthmus at E18.5
• poorly foliated
• thicker than normal
• axons disorganized in lateral regions


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory