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Phenotypes Associated with This Genotype
Genotype
MGI:3802921
Allelic
Composition		 Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iaai mutation (1 available); any Fbxw7 mutation (82 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:137138 )
• 50% of mice develop T cell lymphomas later in life

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:137138 )
• 50% of mice develop T cell lymphomas later in life

immune system
immune system phenotype ( J:137138 )
N
• the numbers of double negative cells are normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory