Phenotypes Associated with This Genotype

Genotype
MGI:3802664

• Allelic Composition: Ppargc1b^tm1.1Dpk/Ppargc1b^tm1.1Dpk
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:137598 )

• fewer than expected mice survive to weaning but are normal

postnatal lethality ( J:137598 )

• fewer than expected mice survive to weaning but are normal

adipose tissue

adipose tissue phenotype ( J:137598 )

N • abnormal body temperature regulation, brown adipose tissue displays normal mitochondrial density and ultrastructure

abnormal brown adipose tissue morphology ( J:137598 )

• triglyceride content of brown adipose tissue is increased compared to in wild-type mice

abnormal fat cell morphology ( J:137598 )

• brown adipocytes exhibit increased lipid droplet size and density compared to in wild-type mice

homeostasis/metabolism

impaired exercise endurance ( J:137598 )

• mice exhibit a shorter mean duration in a low-intensity, run-to-exhaustion exercise protocol compared to similarly treated wild-type mice

impaired adaptive thermogenesis ( J:137598 )

• when subjected to a cold environment for 4 hours without food, mice fail to maintain core body temperature to the same degree as similarly treated wild-type mice

decreased triglyceride level ( J:137598 )

• triglyceride content of brown adipose tissue is increased compared to in wild-type mice

muscle

muscle phenotype ( J:137598 )

N • despite reduced mitochondria state 3 respiration rates, mice exhibit normal muscle cellularity and ultrastructure

abnormal muscle physiology ( J:137598 )

• state 3 respiration rates of mitochondria in the soleus muscle are decreased compared to in wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:137598 )

N • despite abnormal skeletal muscle physiology, cardiac development, structure and function are normal

behavior/neurological

impaired exercise endurance ( J:137598 )

• mice exhibit a shorter mean duration in a low-intensity, run-to-exhaustion exercise protocol compared to similarly treated wild-type mice