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Phenotypes Associated with This Genotype
Genotype
MGI:3801151
Allelic
Composition
Tph2tm1Mca/Tph2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tph2tm1Mca mutation (3 available); any Tph2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 40% reduction in brain 5-HT production

behavior/neurological
• although males do not exhibit increased attacks against a non-aggressive male in a test of social interaction, they do show an increase in threatening postures
• immobility times in the tail suspension test are prolonged
• in the dark-light emergence test, mutants display longer latencies to cross to the lighted compartment and reduced activity in the lighted compartment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory