Phenotypes Associated with This Genotype

Genotype
MGI:3800366

• Allelic Composition: Klf3^tm1Merc/Klf3^tm1Merc
• Genetic Background: FVB.129-Klf3^tm1Merc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:137267 )

• only 17% of mice at weaning are homozygotes instead of the expected 25%

postnatal lethality, incomplete penetrance ( J:137267 )

• expected proportion of homozygotes is found at E14.5 but not at weaning

adipose tissue

decreased total body fat amount ( J:137267 )

• appear leaner

abnormal epididymal fat pad morphology ( J:137267 )

• average cell diameter is about 61% of wild-type and total DNA content is only 56% of wild-type indicating fewer cells are present

abnormal gonadal fat pad morphology ( J:137267 )

• at 12 weeks of age the gonadal fat pad is 38% the size in control littermates

abnormal retroperitoneal fat pad morphology ( J:137267 )

• at 12 weeks of age the retroperitoneal fat pad is 15% the size in control littermates

cellular

abnormal cell differentiation ( J:137267 )

• following exposure to inducers of adipocyte differentiation, MEFs display enhanced lipid accumulation

• however, cell cycle and proliferation are similar to wild-type

growth/size/body

slow postnatal weight gain ( J:137267 )

• similar in size at birth but significantly smaller than littermate controls from 3 to 12 weeks of age