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Phenotypes Associated with This Genotype
Genotype
MGI:3799369
Allelic
Composition
Tg(Trp53R172H)8512Jmr/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53R172H)8512Jmr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

neoplasm
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

cellular
• tumor cells exhibit an increase in genomic instability (tetraploid and aneuploid) compared to tumor cells in wild-type mice

endocrine/exocrine glands
N
• mammary gland development is normal
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

homeostasis/metabolism
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:46246


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory