Phenotypes Associated with This Genotype

Genotype
MGI:3798793

• Allelic Composition: Kdm5a^tm1.1Kael/Kdm5a^tm1.1Kael
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:137333 )

• mice are 20-30% smaller than wild-type littermates

hematopoietic system

abnormal definitive hematopoiesis ( J:137185 )

• myeloid progenitor compartment consisting of common myeloid progenitors (CMP), granulocyte-monocyte progenitors, and megakaryocyte-erythrocyte progenitors, shows significantly decreased rate of apoptosis relative to wild-type

increased neutrophil cell number ( J:137185 )

• 6- or 23-week old mice exhibit relative (44% vs 58% for wild-type vs null) and absolute neutrophilia in peripheral blood compared to control littermates

abnormal hematopoietic stem cell morphology ( J:137185 )

• HSC compartment shows significantly decreased rate of apoptosis relative to wild-type

cellular

abnormal cell cycle ( J:137185 )

• myeloid and HSC progenitors show abnormalities in cell cycle progression such as increased percentages of G0/1 cells in G1 indicating trend toward increased proportion of progenitor cells entering the S/G2/M phase (increased entry into cell cycle)

behavior/neurological

abnormal behavior ( J:137185 , J:137333 )

abnormal involuntary movement ( J:137333 )

• when mice are suspended by the tail, legs tremble

immune system

increased neutrophil cell number ( J:137185 )

• 6- or 23-week old mice exhibit relative (44% vs 58% for wild-type vs null) and absolute neutrophilia in peripheral blood compared to control littermates