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Phenotypes Associated with This Genotype
Genotype
MGI:3798788
Allelic
Composition
Dmdmdx-5Cv/Dmdmdx-5Cv
Genetic
Background
B6Ros.Cg-Dmdmdx-5Cv/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-5Cv mutation (1 available); any Dmd mutation (161 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• despite defects in conduction, mice do not exhibit cardiac fibrosis or cellular hypertrophy in cardiac tissues
• heart rate and ventricular repolarization, reflected on the mouse ECG by the ST interval, are similar to controls
• decreased amplitude and prolonged duration
• sodium current is decreased compared to in wild-type cardiomyocytes

muscle
• compared with wild-type mice
• mice exhibit reduced muscle contractile function compared with wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Duchenne muscular dystrophy DOID:11723 OMIM:310200
J:124861


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory