Mouse Genome Informatics
ht
    Del(5D5Mit73-D5Mit351)5Jcs/+
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

growth/size
• some have misshapened palatine ridges
• Background Sensitivity: severe growth retardation averaging only 50-80% of the weight of same-sex wildtype littermates

craniofacial
• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background
• in some
• in the most severe cases the face is asymmetric and/or the jaw bones are asymmetric
• some have misshapened palatine ridges

hearing/vestibular/ear

limbs/digits/tail

skeleton
• in some

vision/eye
• found in some

digestive/alimentary system
• some have misshapened palatine ridges

behavior/neurological
N
• Morris water maze performance normal (J:67077)
• froglike gait with hindlimbs splayed outward during locomotion
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal

nervous system
• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal
• intraculminate fissure, posterior fissure, and uvular cus are lacking
• hypoplasia of the cerebral cortex results in colliculi being more exposed

Mouse Models of Human Disease
OMIM IDRef(s)
Wolf-Hirschhorn Syndrome; WHS 194190 J:67077