vision/eye
• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls
• 3 of 9 mice have decreased papillary light reflex in response to high intensity light
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• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age
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behavior/neurological
• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls
• 3 of 9 mice have decreased papillary light reflex in response to high intensity light
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nervous system
• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age
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