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Phenotypes Associated with This Genotype
Genotype
MGI:3797741
Allelic
Composition
Opn4tm4(DTA)Saha/Opn4+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4tm4(DTA)Saha mutation (0 available); any Opn4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls
• 3 of 9 mice have decreased papillary light reflex in response to high intensity light
• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age

behavior/neurological
• papillary light reflex is absent when exposed to light bright enough to cause 50% constriction in wild-type controls
• 3 of 9 mice have decreased papillary light reflex in response to high intensity light

nervous system
• only 3.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls
• the degree of ablation for melanopsin-containing retinal ganglion cells increases with age until they are virtually absent at one year of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory