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Phenotypes Associated with This Genotype
Genotype
MGI:3796628
Allelic
Composition
Frem2ne/Frem2ne
Genetic
Background
STOCK Frem2ne/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem2ne mutation (1 available); any Frem2 mutation (92 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Frem2ne/Frem2ne mice exhibit eyelid, eye, digit, ear and coat color abnormalities

vision/eye
• missing eyelid or closed eyelid is the most predominant feature of this mutation

craniofacial
• incomplete penetrance for malformed ear pinnae

limbs/digits/tail
• fused and malformed digits are found with imcomplete penetrance

hearing/vestibular/ear
• incomplete penetrance for malformed ear pinnae

reproductive system
• average 4.5 pups per litter in a homozygoes x heterozygote cross, and average 5.7 pups per litter in a heterozygote x heterozygote cross

pigmentation
• a minority of homozygotes have a slight discoloration of the fur on the head

skeleton

cardiovascular system
N
• heart is normal at 2 months of age

renal/urinary system
N
• kidneys are normal at 2 months of age

integument
• a minority of homozygotes have a slight discoloration of the fur on the head

growth/size/body
• incomplete penetrance for malformed ear pinnae

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:185265 , J:222308


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory