About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3796628
Allelic
Composition
Frem2ne/Frem2ne
Genetic
Background
STOCK Frem2ne/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem2ne mutation (1 available); any Frem2 mutation (137 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Frem2ne/Frem2ne mice exhibit eyelid, eye, digit, ear and coat color abnormalities

vision/eye
• missing eyelid or closed eyelid is the most predominant feature of this mutation

craniofacial
• incomplete penetrance for malformed ear pinnae

limbs/digits/tail
• fused and malformed digits are found with imcomplete penetrance

hearing/vestibular/ear
• incomplete penetrance for malformed ear pinnae

reproductive system
• average 4.5 pups per litter in a homozygoes x heterozygote cross, and average 5.7 pups per litter in a heterozygote x heterozygote cross

pigmentation
• a minority of homozygotes have a slight discoloration of the fur on the head

skeleton

cardiovascular system
N
• heart is normal at 2 months of age

renal/urinary system
N
• kidneys are normal at 2 months of age

integument
• a minority of homozygotes have a slight discoloration of the fur on the head

growth/size/body
• incomplete penetrance for malformed ear pinnae

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:185265 , J:222308


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory