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Phenotypes Associated with This Genotype
Genotype
MGI:3795697
Allelic
Composition		 Gt(ROSA)26Sortm1(RARA*)Soc/Gt(ROSA)26Sortm1(RARA*)Soc
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (30 available)
Gt(ROSA)26Sortm1(RARA*)Soc mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
telencephalon hypoplasia ( J:135403 )
• at E10.5, mice exhibit a 15% decrease in cell proliferation in the dorsal telencephalic progenitors due to slowed cell cycle progression compared to in control mice
• at E10.5, apoptosis is increased 5-fold in the pallium and 4-fold in the subpallium compared to in control mice
abnormal medial ganglionic eminence morphology ( J:135403 )
• Nkx2.1+ progenitor cells in the medial ganglionic eminence are mispecified

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory