Phenotypes Associated with This Genotype

Genotype
MGI:3795356

• Allelic Composition: Pou3f2^tm1Tno/Pou3f2^tm1Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:30429 )

• homozygotes are born live and do not display obvious abnormalities but begin to die within several hours; more than half die within 2 days and all die within 10 days of birth

growth/size/body

postnatal growth retardation ( J:30429 )

• mice surviving >2 days display markedly retarded growth; body weight is half that of normal littermates at 4 days of age

endocrine/exocrine glands

abnormal neurohypophysis morphology ( J:30429 )

• posterior lobe is severely hypoplastic at 4 days of age

• no vasopressin-expressing nerve fibers are detected in posterior lobe

nervous system

abnormal neurohypophysis morphology ( J:30429 )

• posterior lobe is severely hypoplastic at 4 days of age

• no vasopressin-expressing nerve fibers are detected in posterior lobe

abnormal hypothalamus morphology ( J:30429 )

• the paraventricular nucleus and supraoptic nucleus are missing in mutant hypothalamus

• median eminence is extremely hypoplastic; anuclear light region of median eminence is specifically impaired

• all neurons forming the paraventricular nucleus (PVN) and supraoptic (SO) nucleus, including magnocellular neurons, are absent

• parvocellular neurons (that synthesize and secrete corticotropin-releasing factor, CRF and thyrotropin-releasing hormone, TRH) are absent from PVN

• somatostatinergic neurons in periventricular (PEV) region are absent

abnormal neuronal precursor cell number ( J:30429 )

• vasopressin-positive neuronal precursors are absent in hypothalamus at E14.5; neuronal precursors for PVN and SO die around E12.5 during migration from ventricular region

adipose tissue

absent subcutaneous adipose tissue ( J:30429 )

• subcutaneous adipose tissues are totally absent

abnormal brown adipose tissue morphology ( J:30429 )

• depots in mouse back do not contain any fatty deposition

liver/biliary system

hepatic steatosis ( J:30429 )

• fatty liver persists in mice surviving 1 week

integument

absent subcutaneous adipose tissue ( J:30429 )

• subcutaneous adipose tissues are totally absent